Modular injectable matrices based on alginate solution/microsphere mixtures that gel in situ and co-deliver immunomodulatory factors
نویسندگان
چکیده
منابع مشابه
Modular injectable matrices based on alginate solution/microsphere mixtures that gel in situ and co-deliver immunomodulatory factors.
Biocompatible polymer solutions that can crosslink in situ following injection to form stable hydrogels are of interest as depots for sustained delivery of therapeutic factors or cells, and as scaffolds for regenerative medicine. Here, injectable self-gelling alginate formulations obtained by mixing alginate microspheres (as calcium reservoirs) with soluble alginate solutions were characterized...
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The oral delivery of drugs with a narrow absorption window in the gastrointestinal tract (GIT) is often limited by poor bioavailability with conventional dosage forms due to incomplete drug release and short residence time at the site of absorption. In-situ gel provides the best way to overcome problems of immediate release and short gastrointestinal residence of liquids. The in situ gel dosage...
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ژورنال
عنوان ژورنال: Acta Biomaterialia
سال: 2009
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2008.11.019